Ontology highlight
ABSTRACT:
SUBMITTER: Chu I
PROVIDER: S-EPMC1961623 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Chu Isabel I Sun Jun J Arnaout Angel A Kahn Harriette H Hanna Wedad W Narod Steven S Sun Ping P Tan Cheng-Keat CK Hengst Ludger L Slingerland Joyce J
Cell 20070101 2
The kinase inhibitor p27Kip1 regulates the G1 cell cycle phase. Here, we present data indicating that the oncogenic kinase Src regulates p27 stability through phosphorylation of p27 at tyrosine 74 and tyrosine 88. Src inhibitors increase cellular p27 stability, and Src overexpression accelerates p27 proteolysis. Src-phosphorylated p27 is shown to inhibit cyclin E-Cdk2 poorly in vitro, and Src transfection reduces p27-cyclin E-Cdk2 complexes. Our data indicate that phosphorylation by Src impairs ...[more]