Ontology highlight
ABSTRACT:
SUBMITTER: Tsytlonok M
PROVIDER: S-EPMC6459857 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Nature communications 20190411 1
p27<sup>Kip1</sup> is an intrinsically disordered protein (IDP) that inhibits cyclin-dependent kinase (Cdk)/cyclin complexes (e.g., Cdk2/cyclin A), causing cell cycle arrest. Cell division progresses when stably Cdk2/cyclin A-bound p27 is phosphorylated on one or two structurally occluded tyrosine residues and a distal threonine residue (T187), triggering degradation of p27. Here, using an integrated biophysical approach, we show that Cdk2/cyclin A-bound p27 samples lowly-populated conformations ...[more]