Ontology highlight
ABSTRACT:
SUBMITTER: Perry JJ
PROVIDER: S-EPMC3308628 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Perry J Jefferson P JJ Tainer John A JA
Science signaling 20110405 167
Ataxia-telangiectasia (A-T) is a rare, neurodegenerative, inherited disease arising from mutations in the kinase A-T mutated (ATM), which promotes cell cycle checkpoints and DNA double-strand break repair. Puzzlingly, these ATM activities fail to fully explain A-T neuropathologies, which instead have links to stress induced by reactive oxygen species (ROS). However, a landmark discovery reveals an unexpected intersection of ROS and kinase signaling: ATM can be directly activated by oxidation to ...[more]