Ontology highlight
ABSTRACT:
SUBMITTER: Ghosal D
PROVIDER: S-EPMC6879910 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Ghosal Debnath D Kim Ki Woo KW Zheng Huaixin H Kaplan Mohammed M Truchan Hilary K HK Lopez Alberto E AE McIntire Ian E IE Vogel Joseph P JP Cianciotto Nicholas P NP Jensen Grant J GJ
Nature microbiology 20191121 12
The type II secretion system (T2SS) is a multiprotein envelope-spanning assembly that translocates a wide range of virulence factors, enzymes and effectors through the outer membrane of many Gram-negative bacteria<sup>1-3</sup>. Here, using electron cryotomography and subtomogram averaging methods, we reveal the in vivo structure of an intact T2SS imaged within the human pathogen Legionella pneumophila. Although the T2SS has only limited sequence and component homology with the evolutionarily re ...[more]