Ontology highlight
ABSTRACT:
SUBMITTER: Matos MF
PROVIDER: S-EPMC3309763 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Matos Maria F MF Xu Yibin Y Dulubova Irina I Otwinowski Zbyszek Z Richardson John M JM Tomchick Diana R DR Rizo Josep J Ho Angela A
Proceedings of the National Academy of Sciences of the United States of America 20120221 10
Mint adaptor proteins bind to the amyloid precursor protein (APP) and regulate APP processing associated with Alzheimer's disease; however, the molecular mechanisms underlying Mint regulation in APP binding and processing remain unclear. Biochemical, biophysical, and cellular experiments now show that the Mint1 phosphotyrosine binding (PTB) domain that binds to APP is intramolecularly inhibited by the adjacent C-terminal linker region. The crystal structure of a C-terminally extended Mint1 PTB f ...[more]