Ontology highlight
ABSTRACT:
SUBMITTER: Joo W
PROVIDER: S-EPMC3310437 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Joo Woo W Xu Guozhou G Persky Nicole S NS Smogorzewska Agata A Rudge Derek G DG Buzovetsky Olga O Elledge Stephen J SJ Pavletich Nikola P NP
Science (New York, N.Y.) 20110701 6040
Fanconi anemia is a cancer predisposition syndrome caused by defects in the repair of DNA interstrand cross-links (ICLs). Central to this pathway is the Fanconi anemia I-Fanconi anemia D2 (FANCI-FANCD2) (ID) complex, which is activated by DNA damage-induced phosphorylation and monoubiquitination. The 3.4 angstrom crystal structure of the ~300 kilodalton ID complex reveals that monoubiquitination and regulatory phosphorylation sites map to the I-D interface, suggesting that they occur on monomeri ...[more]