Ontology highlight
ABSTRACT:
SUBMITTER: Lopez-Martinez D
PROVIDER: S-EPMC6581795 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Lopez-Martinez David D Kupculak Marian M Yang Di D Yoshikawa Yasunaga Y Liang Chih-Chao CC Wu Ronghu R Gygi Steven P SP Cohn Martin A MA
Cell reports 20190601 10
Interstrand crosslinks (ICLs) of the DNA helix are a deleterious form of DNA damage. ICLs can be repaired by the Fanconi anemia pathway. At the center of the pathway is the FANCD2/FANCI complex, recruitment of which to DNA is a critical step for repair. After recruitment, monoubiquitination of both FANCD2 and FANCI leads to their retention on chromatin, ensuring subsequent repair. However, regulation of recruitment is poorly understood. Here, we report a cluster of phosphosites on FANCD2 whose p ...[more]