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Carbon nanotube thin film biosensors for sensitive and reproducible whole virus detection.

ABSTRACT: Here, we report the label-free, sensitive, and real-time electrical detection of whole viruses using carbon nanotube thin film (CNT-TF) field effect devices. Selective detection of approximately 550 model viruses, M13-bacteriophage, is demonstrated using a simple two-terminal (no gate electrode) configuration. Chemical gating through specific antibody-virus binding on CNT surface is proposed to be the sensing mechanism. Compared to electrical impedance sensors with identical microelectrode dimensions (no CNT), the CNT-TF sensors exhibit sensitivity 5 orders higher. We believe the reported approach could lead to a reproducible and cost-effective solution for rapid viral identification.

SUBMITTER: Mandal HS

PROVIDER: S-EPMC3311235 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Carbon nanotube thin film biosensors for sensitive and reproducible whole virus detection.

Mandal Himadri S HS Su Zhengding Z Ward Andrew A Tang Xiaowu Shirley XS

Theranostics 20120301 3

Here, we report the label-free, sensitive, and real-time electrical detection of whole viruses using carbon nanotube thin film (CNT-TF) field effect devices. Selective detection of approximately 550 model viruses, M13-bacteriophage, is demonstrated using a simple two-terminal (no gate electrode) configuration. Chemical gating through specific antibody-virus binding on CNT surface is proposed to be the sensing mechanism. Compared to electrical impedance sensors with identical microelectrode dimen ...[more]

PMID: 22448194

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