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An orthosteric inhibitor of the Ras-Sos interaction.

ABSTRACT: Mimics of ?-helices on protein surfaces have emerged as powerful reagents for antagonizing protein-protein interactions, which are difficult to target with small molecules. Here we describe the design of a cell-permeable synthetic ?-helix, based on the guanine nucleotide exchange factor Sos, that interferes with Ras-Sos interaction and downregulates Ras signaling in response to receptor tyrosine kinase activation.

SUBMITTER: Patgiri A

PROVIDER: S-EPMC3312813 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature

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An orthosteric inhibitor of the Ras-Sos interaction.

Patgiri Anupam A Yadav Kamlesh K KK Arora Paramjit S PS Bar-Sagi Dafna D

Nature chemical biology 20110717 9

Mimics of α-helices on protein surfaces have emerged as powerful reagents for antagonizing protein-protein interactions, which are difficult to target with small molecules. Here we describe the design of a cell-permeable synthetic α-helix, based on the guanine nucleotide exchange factor Sos, that interferes with Ras-Sos interaction and downregulates Ras signaling in response to receptor tyrosine kinase activation. ...[more]

PMID: 21765406

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A Sos Proteomimetic as a Pan-Ras Inhibitor

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