Ontology highlight
ABSTRACT:
SUBMITTER: Hoffman AM
PROVIDER: S-EPMC3314381 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Epigenomics 20110201 1
This article focuses on the epigenetic alterations of aberrant promoter hypermethylation of genes, and histone modifications or RNA interference in cancer cells. Current knowledge of the hypermethylation of allele(s) in classical tumor suppressor genes in inherited and sporadic cancer, candidate tumor suppressor and other cancer genes is summarized gene by gene. Global and array-based studies of tumor cell hypermethylation are discussed. The importance of standardization of scoring of the methyl ...[more]