Ontology highlight
ABSTRACT:
SUBMITTER: Agromayor M
PROVIDER: S-EPMC3314968 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Agromayor Monica M Soler Nicolas N Caballe Anna A Kueck Tonya T Freund Stefan M SM Allen Mark D MD Bycroft Mark M Perisic Olga O Ye Yu Y McDonald Bethan B Scheel Hartmut H Hofmann Kay K Neil Stuart J D SJ Martin-Serrano Juan J Williams Roger L RL
Structure (London, England : 1993) 20120301 3
The endosomal sorting complexes required for transport (ESCRTs) facilitate endosomal sorting of ubiquitinated cargo, MVB biogenesis, late stages of cytokinesis, and retroviral budding. Here we show that ubiquitin associated protein 1 (UBAP1), a subunit of human ESCRT-I, coassembles in a stable 1:1:1:1 complex with Vps23/TSG101, VPS28, and VPS37. The X-ray crystal structure of the C-terminal region of UBAP1 reveals a domain that we describe as a solenoid of overlapping UBAs (SOUBA). NMR analysis ...[more]