Ontology highlight
ABSTRACT:
SUBMITTER: Gahloth D
PROVIDER: S-EPMC5145805 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Gahloth Deepankar D Levy Colin C Heaven Graham G Stefani Flavia F Wunderley Lydia L Mould Paul P Cliff Matthew J MJ Bella Jordi J Fielding Alistair J AJ Woodman Philip P Tabernero Lydia L
Structure (London, England : 1993) 20161110 12
Endosomal sorting complexes required for transport (ESCRTs) are essential for ubiquitin-dependent degradation of mitogenic receptors, a process often compromised in cancer pathologies. Sorting of ubiquinated receptors via ESCRTs is controlled by the tumor suppressor phosphatase HD-PTP. The specific interaction between HD-PTP and the ESCRT-I subunit UBAP1 is critical for degradation of growth factor receptors and integrins. Here, we present the structural characterization by X-ray crystallography ...[more]