Ontology highlight
ABSTRACT:
SUBMITTER: Arakawa H
PROVIDER: S-EPMC3315315 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Arakawa Hiroshi H Bednar Theresa T Wang Minli M Paul Katja K Mladenov Emil E Bencsik-Theilen Alena A AA Iliakis George G
Nucleic acids research 20111129 6
In eukaryotes, the three families of ATP-dependent DNA ligases are associated with specific functions in DNA metabolism. DNA ligase I (LigI) catalyzes Okazaki-fragment ligation at the replication fork and nucleotide excision repair (NER). DNA ligase IV (LigIV) mediates repair of DNA double strand breaks (DSB) via the canonical non-homologous end-joining (NHEJ) pathway. The evolutionary younger DNA ligase III (LigIII) is restricted to higher eukaryotes and has been associated with base excision ( ...[more]