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Castration-resistant prostate cancer: mechanisms, targets, and treatment.

ABSTRACT: Patients with castration-resistant prostate cancer (CRPC), who progress after docetaxel therapy, had until very recently, only a few therapeutic options. Recent advances in this field brought about new perspectives in the treatment of this disease. Molecular, basic, and translational research has given us a better understanding on the mechanisms of CRPC. This great investment has turned into a more rational approach to the development of new drugs. Some of the new treatments are already available to our patients outside clinical trials and may include inhibitors of androgen biosynthesis; new chemotherapy agents; bone-targeted therapy; and immunotherapy. This paper aims to review the mechanisms of prostate cancer resistance, possible therapeutic targets, as well as new options to treat CRPC.

SUBMITTER: Amaral TM

PROVIDER: S-EPMC3316959 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Castration-resistant prostate cancer: mechanisms, targets, and treatment.

Amaral Teresa Maria Santos TM Macedo Daniela D Fernandes Isabel I Costa Luis L

Prostate cancer 20120305

Patients with castration-resistant prostate cancer (CRPC), who progress after docetaxel therapy, had until very recently, only a few therapeutic options. Recent advances in this field brought about new perspectives in the treatment of this disease. Molecular, basic, and translational research has given us a better understanding on the mechanisms of CRPC. This great investment has turned into a more rational approach to the development of new drugs. Some of the new treatments are already availabl ...[more]

PMID: 22530130

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