Ontology highlight
ABSTRACT:
SUBMITTER: Jeannot K
PROVIDER: S-EPMC3318365 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Jeannot Katy K Poirel Laurent L Robert-Nicoud Marjorie M Cholley Pascal P Nordmann Patrice P Plésiat Patrick P
Antimicrobial agents and chemotherapy 20120130 4
Analysis of two clonally related multiresistant Pseudomonas aeruginosa isolates led to the identification of a novel IMP-type metallo-β-lactamase. IMP-29 was significantly different from the other IMP variants (the closest variant being IMP-5 with 93% amino acid identity). The bla(IMP-29) gene cassette was carried by a class 1 integron in strain 10.298, while in strain 10.266 it was located in a rearranged DNA region on a 30-kb conjugative plasmid. Biochemical analysis confirmed that IMP-29 effi ...[more]