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IMP-29, a novel IMP-type metallo-?-lactamase in Pseudomonas aeruginosa.


ABSTRACT: Analysis of two clonally related multiresistant Pseudomonas aeruginosa isolates led to the identification of a novel IMP-type metallo-?-lactamase. IMP-29 was significantly different from the other IMP variants (the closest variant being IMP-5 with 93% amino acid identity). The bla(IMP-29) gene cassette was carried by a class 1 integron in strain 10.298, while in strain 10.266 it was located in a rearranged DNA region on a 30-kb conjugative plasmid. Biochemical analysis confirmed that IMP-29 efficiently hydrolyzed carbapenems.

SUBMITTER: Jeannot K 

PROVIDER: S-EPMC3318365 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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IMP-29, a novel IMP-type metallo-β-lactamase in Pseudomonas aeruginosa.

Jeannot Katy K   Poirel Laurent L   Robert-Nicoud Marjorie M   Cholley Pascal P   Nordmann Patrice P   Plésiat Patrick P  

Antimicrobial agents and chemotherapy 20120130 4


Analysis of two clonally related multiresistant Pseudomonas aeruginosa isolates led to the identification of a novel IMP-type metallo-β-lactamase. IMP-29 was significantly different from the other IMP variants (the closest variant being IMP-5 with 93% amino acid identity). The bla(IMP-29) gene cassette was carried by a class 1 integron in strain 10.298, while in strain 10.266 it was located in a rearranged DNA region on a 30-kb conjugative plasmid. Biochemical analysis confirmed that IMP-29 effi  ...[more]

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