Ontology highlight
ABSTRACT:
SUBMITTER: Tada T
PROVIDER: S-EPMC4604376 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20150817 11
A meropenem-resistant Pseudomonas aeruginosa isolate was obtained from a patient in a medical setting in Hanoi, Vietnam. The isolate was found to have a novel IMP-type metallo-β-lactamase, IMP-51, which differed from IMP-7 by an amino acid substitution (Ser262Gly). Escherichia coli expressing blaIMP-51 showed greater resistance to cefoxitin, meropenem, and moxalactam than E. coli expressing blaIMP-7. The amino acid residue at position 262 was located near the active site, proximal to the H263 Zn ...[more]