Ontology highlight
ABSTRACT:
SUBMITTER: Watanabe T
PROVIDER: S-EPMC3318582 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Watanabe Takehisa T Ishihara Ko K Hirosue Akiyuki A Watanabe Sugiko S Hino Shinjiro S Ojima Hidenori H Kanai Yae Y Sasaki Yutaka Y Nakao Mitsuyoshi M
Molecular and cellular biology 20120221 8
The three-dimensional context of endogenous chromosomal regions may contribute to the regulation of gene clusters by influencing interactions between transcriptional regulatory elements. In this study, we investigated the effects of tumor necrosis factor (TNF) signaling on spatiotemporal enhancer-promoter interactions in the human tumor necrosis factor (TNF)/lymphotoxin (LT) gene locus, mediated by CCCTC-binding factor (CTCF)-dependent chromatin insulators. The cytokine genes LTα, TNF, and LTβ a ...[more]