Ontology highlight
ABSTRACT:
SUBMITTER: Yang R
PROVIDER: S-EPMC4838340 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Yang Rui R Kerschner Jenny L JL Gosalia Nehal N Neems Daniel D Gorsic Lidija K LK Safi Alexias A Crawford Gregory E GE Kosak Steven T ST Leir Shih-Hsing SH Harris Ann A
Nucleic acids research 20151215 7
Higher order chromatin structure establishes domains that organize the genome and coordinate gene expression. However, the molecular mechanisms controlling transcription of individual loci within a topological domain (TAD) are not fully understood. The cystic fibrosis transmembrane conductance regulator (CFTR) gene provides a paradigm for investigating these mechanisms.CFTR occupies a TAD bordered by CTCF/cohesin binding sites within which are cell-type-selective cis-regulatory elements for the ...[more]