Ontology highlight
ABSTRACT:
SUBMITTER: Lim HN
PROVIDER: S-EPMC3320024 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Lim Hee Nam HN Parker Kathlyn A KA
Journal of the American Chemical Society 20111129 50
The first total synthesis of (-)-arabilin, a Streptomyces metabolite that inhibits hormone activation of the androgen receptor, has been completed. The key step, a [1,7]-hydrogen shift, establishes the enol ether-containing skipped-tetraene substructure. This nonenzymatic pericyclic reaction is considered to be biomimetic. ...[more]