Ontology highlight
ABSTRACT:
SUBMITTER: McDonald BR
PROVIDER: S-EPMC4284651 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
McDonald Benjamin R BR Nibbs Antoinette E AE Scheidt Karl A KA
Organic letters 20141217 1
We report the first asymmetric, total synthesis of (-)-isosilybin A. A late-stage catalytic biomimetic cyclization of a highly functionalized chalcone is employed to form the characteristic benzopyranone ring. A robust and flexible approach to this chalcone provides an entry to the preparation of the entire isomeric family of silybin natural products. ...[more]