Ontology highlight
ABSTRACT:
SUBMITTER: Plikus MV
PROVIDER: S-EPMC3321266 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Plikus Maksim V MV Baker Ruth E RE Chen Chih-Chiang CC Fare Clyde C de la Cruz Damon D Andl Thomas T Maini Philip K PK Millar Sarah E SE Widelitz Randall R Chuong Cheng-Ming CM
Science (New York, N.Y.) 20110401 6029
Stem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative behavior in a hair follicle population. By combining predictive mathematical modeling with in vivo studies in mice and rabbits, we show that a follicle progresses through cycling stages by continuous integration of inputs from intrinsic follicular ...[more]