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Self-organizing and stochastic behaviors during the regeneration of hair stem cells.


ABSTRACT: Stem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative behavior in a hair follicle population. By combining predictive mathematical modeling with in vivo studies in mice and rabbits, we show that a follicle progresses through cycling stages by continuous integration of inputs from intrinsic follicular and extrinsic environmental signals based on universal patterning principles. Signaling from the WNT/bone morphogenetic protein activator/inhibitor pair is coopted to mediate interactions among follicles in the population. This regenerative strategy is robust and versatile because relative activator/inhibitor strengths can be modulated easily, adapting the organism to different physiological and evolutionary needs.

SUBMITTER: Plikus MV 

PROVIDER: S-EPMC3321266 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature

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Self-organizing and stochastic behaviors during the regeneration of hair stem cells.

Plikus Maksim V MV   Baker Ruth E RE   Chen Chih-Chiang CC   Fare Clyde C   de la Cruz Damon D   Andl Thomas T   Maini Philip K PK   Millar Sarah E SE   Widelitz Randall R   Chuong Cheng-Ming CM  

Science (New York, N.Y.) 20110401 6029


Stem cells cycle through active and quiescent states. Large populations of stem cells in an organ may cycle randomly or in a coordinated manner. Although stem cell cycling within single hair follicles has been studied, less is known about regenerative behavior in a hair follicle population. By combining predictive mathematical modeling with in vivo studies in mice and rabbits, we show that a follicle progresses through cycling stages by continuous integration of inputs from intrinsic follicular  ...[more]

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