Ontology highlight
ABSTRACT:
SUBMITTER: Rothhaar TL
PROVIDER: S-EPMC3322458 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Rothhaar Tatjana L TL Grösgen Sven S Haupenthal Viola J VJ Burg Verena K VK Hundsdörfer Benjamin B Mett Janine J Riemenschneider Matthias M Grimm Heike S HS Hartmann Tobias T Grimm Marcus O W MO
TheScientificWorldJournal 20120401
Lipids play an important role as risk or protective factors in Alzheimer's disease (AD). Previously it has been shown that plasmalogens, the major brain phospholipids, are altered in AD. However, it remained unclear whether plasmalogens themselves are able to modulate amyloid precursor protein (APP) processing or if the reduced plasmalogen level is a consequence of AD. Here we identify the plasmalogens which are altered in human AD postmortem brains and investigate their impact on APP processing ...[more]