Ontology highlight
ABSTRACT:
SUBMITTER: Park S
PROVIDER: S-EPMC3322870 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Park Sungman S Kim Donghwa D Dan Han C HC Chen Huihua H Testa Joseph R JR Cheng Jin Q JQ
The Journal of biological chemistry 20120214 14
Akt regulates a diverse array of cellular functions, including cell survival, proliferation, differentiation, and metabolism. Although a number of molecules have been identified as upstream regulators and downstream targets of Akt, the mechanisms by which Akt regulates these cellular processes remain elusive. Here, we demonstrate that a novel transcription factor, PHF20/TZP (referring to Tudor and zinc finger domain containing protein), binds to Akt and induces p53 expression at the transcriptio ...[more]