Thrombospondin-4 is required for stretch-mediated contractility augmentation in cardiac muscle.

ABSTRACT:

Rationale

One of the physiological mechanisms by which the heart adapts to a rise in blood pressure is by augmenting myocyte stretch-mediated intracellular calcium, with a subsequent increase in contractility. This slow force response was first described over a century ago and has long been considered compensatory, but its underlying mechanisms and link to chronic adaptations remain uncertain. Because levels of the matricellular protein thrombospondin-4 (TSP4) rapidly rise in hypertension and are elevated in cardiac stress overload and heart failure, we hypothesized that TSP4 is involved in this adaptive mechanism.

Objective

To determine the mechano-transductive role that TSP4 plays in cardiac regulation to stress.

Methods and results

In mice lacking TSP4 (Tsp4⁻/⁻), h

SUBMITTER: Cingolani OH 

PROVIDER: S-EPMC3324097 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature