Ontology highlight
ABSTRACT:
SUBMITTER: Ahmad MF
PROVIDER: S-EPMC3324464 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Ahmad Mohammad Faiz MF Yadav Bhawna B Kumar Pravin P Puri Amrita A Mazumder Mohit M Ali Anwar A Gourinath Samudrala S Muthuswami Rohini R Komath Sneha Sudha SS
PloS one 20120411 4
<h4>Background</h4>Proteins destined to be Glycosylphosphatidylinositol (GPI) anchored are translocated into the ER lumen completely before the C-terminal GPI anchor attachment signal sequence (SS) is removed by the GPI-transamidase and replaced by a pre-formed GPI anchor precursor. Does the SS have a role in dictating the conformation and function of the protein as well?<h4>Methodology/principal findings</h4>We generated two variants of the Als5 protein without and with the SS in order to addre ...[more]