Ontology highlight
ABSTRACT:
SUBMITTER: Nicholson TB
PROVIDER: S-EPMC2064130 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Nicholson Thomas B TB Stanners Clifford P CP
The Journal of cell biology 20070416 2
Exchanging the glycophosphatidylinositol (GPI) anchor signal sequence of neural cell adhesion molecule (NCAM) for the signal sequence of carcinoembryonic antigen (CEA) generates a mature protein with NCAM external domains but CEA-like tumorigenic activity. We hypothesized that this resulted from the presence of a functional specificity signal within this sequence and generated CEA/NCAM chimeras to identify this signal. Replacing the residues (GLSAG) 6-10 amino acids downstream of the CEA anchor ...[more]