Ontology highlight
ABSTRACT:
SUBMITTER: Sebastian D
PROVIDER: S-EPMC3325712 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Sebastián David D Hernández-Alvarez María Isabel MI Segalés Jessica J Sorianello Eleonora E Muñoz Juan Pablo JP Sala David D Waget Aurélie A Liesa Marc M Paz José C JC Gopalacharyulu Peddinti P Orešič Matej M Pich Sara S Burcelin Rémy R Palacín Manuel M Zorzano Antonio A
Proceedings of the National Academy of Sciences of the United States of America 20120316 14
Mitochondria are dynamic organelles that play a key role in energy conversion. Optimal mitochondrial function is ensured by a quality-control system tightly coupled to fusion and fission. In this connection, mitofusin 2 (Mfn2) participates in mitochondrial fusion and undergoes repression in muscle from obese or type 2 diabetic patients. Here, we provide in vivo evidence that Mfn2 plays an essential role in metabolic homeostasis. Liver-specific ablation of Mfn2 in mice led to numerous metabolic a ...[more]