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Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial internalization.

ABSTRACT: Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH(A) through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.

SUBMITTER: Lin LY

PROVIDER: S-EPMC3325780 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Synthetic polymer nanoparticles conjugated with FimH(A) from E. coli pili to emulate the bacterial mode of epithelial internalization.

Lin Lily Yun LY Tiemann Kristin M KM Li Yali Y Pinkner Jerome S JS Walker Jennifer N JN Hultgren Scott J SJ Hunstad David A DA Wooley Karen L KL

Journal of the American Chemical Society 20120223 9

Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH(A) through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro. ...[more]

PMID: 22360307

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