Ontology highlight
ABSTRACT:
SUBMITTER: Bao H
PROVIDER: S-EPMC3328499 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
PloS one 20120417 4
The maltose transporter MalFGK(2), together with the substrate-binding protein MalE, is one of the best-characterized ABC transporters. In the conventional model, MalE captures maltose in the periplasm and delivers the sugar to the transporter. Here, using nanodiscs and proteoliposomes, we instead find that MalE is bound with high-affinity to MalFGK2 to facilitate the acquisition of the sugar. When the maltose concentration exceeds the transport capacity, MalE captures maltose and dissociates fr ...[more]