Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC3743091 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Current opinion in structural biology 20130427 4
ATP-binding cassette (ABC) transporters are ubiquitous membrane proteins that import and export a large variety of materials across the lipid bilayer. A key question that drives ABC transporter research is how ATP hydrolysis is coupled to substrate translocation. This review uses the maltose transporter of Escherichia coli as a model system to understand the molecular mechanism of ABC importers. X-ray crystallography was used to capture the structures of the maltose transporter in multiple confo ...[more]