Ontology highlight
ABSTRACT:
SUBMITTER: Skare O
PROVIDER: S-EPMC3334353 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Skare Oivind O Jugessur Astanand A Lie Rolv Terje RT Wilcox Allen James AJ Murray Jeffrey Clark JC Lunde Astrid A Nguyen Truc Trung TT Gjessing Håkon Kristian HK
Annals of human genetics 20120501 3
Orofacial clefts are common birth defects with strong evidence for both genetic and environmental causal factors. Candidate gene studies combined with exposures known to influence the outcome provide a highly targeted approach to detecting GxE interactions. We developed a new statistical approach that combines the case-control and offspring-parent triad designs into a "hybrid design" to search for GxE interactions among 334 autosomal cleft candidate genes and maternal first-trimester exposure to ...[more]