Ontology highlight
ABSTRACT:
SUBMITTER: Lungu OI
PROVIDER: S-EPMC3334866 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Chemistry & biology 20120401 4
Photocontrol of functional peptides is a powerful tool for spatial and temporal control of cell signaling events. We show that the genetically encoded light-sensitive LOV2 domain of Avena Sativa phototropin 1 (AsLOV2) can be used to reversibly photomodulate the affinity of peptides for their binding partners. Sequence analysis and molecular modeling were used to embed two peptides into the Jα helix of the AsLOV2 domain while maintaining AsLOV2 structure in the dark but allowing for binding to ef ...[more]