Ontology highlight
ABSTRACT:
SUBMITTER: Zeyat G
PROVIDER: S-EPMC3388879 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20120618
Photoswitchable peptides were synthesized by using cysteine- and auxiliary-based native chemical ligation reactions. For this purpose, the two regioisomeric azobenzene building blocks 3,4'-AMPB thioester 1b and 4,4'-AMPB thioester 2b were employed in the ligation reactions. While 4,4'-AMPB requires the 4,5,6-trimethoxy-2-mercaptobenzyl auxiliary to minimize reduction of the diazene unit, 3,4'-AMPB can be used in combination with the 4,5,6-trimethoxy-2-mercaptobenzyl auxiliary as well as the N(α) ...[more]