Ontology highlight
ABSTRACT:
SUBMITTER: Yi JJ
PROVIDER: S-EPMC4277778 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
ACS synthetic biology 20140613 11
Optogenetic control of endogenous signaling can be an important tool for probing cell behavior. Using the photoresponse of the LOV2 domain of Avena sativa phototropin 1, we developed analogues of kinase inhibitors whose activity is light dependent. Inhibitory peptides were appended to the Jα helix, where they potently inhibited kinases in the light but were sterically blocked from kinase interaction in the dark. Photoactivatable inhibitors for cyclic-AMP dependent kinase (PKA) and myosin light c ...[more]