Ontology highlight
ABSTRACT:
SUBMITTER: Pressman S
PROVIDER: S-EPMC3337472 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Pressman Sigal S Reinke Catherine A CA Wang Xiaohong X Carthew Richard W RW
G3 (Bethesda, Md.) 20120401 4
A central goal of microRNA biology is to elucidate the genetic program of miRNA function and regulation. However, relatively few of the effectors that execute miRNA repression have been identified. Because such genes may function in many developmental processes, mutations in them are expected to be pleiotropic and thus are discarded in most standard genetic screens. Here, we describe a systematic screen designed to identify all Drosophila genes in ∼40% of the genome that function in the miRNA pa ...[more]