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Systematic screen of chemotherapeutics in Drosophila stem cell tumors.

ABSTRACT: Here we report the development of an in vivo system to study the interaction of stem cells with drugs using a tumor model in the adult Drosophila intestine. Strikingly, we find that some Food and Drug Administration-approved chemotherapeutics that can inhibit the growth of Drosophila tumor stem cells can paradoxically promote the hyperproliferation of their wild-type counterparts. These results reveal an unanticipated side effect on stem cells that may contribute to tumor recurrence. We propose that the same side effect may occur in humans based on our finding that it is driven in Drosophila by the evolutionarily conserved Janus kinase-signal transducers and activators of transcription (JAK-STAT) pathway. An immediate implication of our findings is that supplementing traditional chemotherapeutics with anti-inflammatories may reduce tumor recurrence.

SUBMITTER: Markstein M

PROVIDER: S-EPMC3970492 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Systematic screen of chemotherapeutics in Drosophila stem cell tumors.

Markstein Michele M Dettorre Samantha S Cho Julio J Neumüller Ralph A RA Craig-Müller Sören S Perrimon Norbert N

Proceedings of the National Academy of Sciences of the United States of America 20140310 12

Here we report the development of an in vivo system to study the interaction of stem cells with drugs using a tumor model in the adult Drosophila intestine. Strikingly, we find that some Food and Drug Administration-approved chemotherapeutics that can inhibit the growth of Drosophila tumor stem cells can paradoxically promote the hyperproliferation of their wild-type counterparts. These results reveal an unanticipated side effect on stem cells that may contribute to tumor recurrence. We propose ...[more]

PMID: 24616500

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