Ontology highlight
ABSTRACT:
SUBMITTER: Nelson SA
PROVIDER: S-EPMC3338500 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Nelson Scott A SA Sanson Anthony M AM Park Hay-Oak HO Cooper John A JA
PloS one 20120425 4
The spindle position checkpoint (SPC) ensures correct mitotic spindle position before allowing mitotic exit in the budding yeast Saccharomyces cerevisiae. In a candidate screen for checkpoint genes, we identified bud2Δ as deficient for the SPC. Bud2 is a GTPase activating protein (GAP), and the only known substrate of Bud2 was Rsr1/Bud1, a Ras-like GTPase and a central component of the bud-site-selection pathway. Mutants lacking Rsr1/Bud1 had no checkpoint defect, as did strains lacking and over ...[more]