Ontology highlight
ABSTRACT:
SUBMITTER: Katz C
PROVIDER: S-EPMC3340256 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Katz Chen C Zaltsman-Amir Yehudit Y Mostizky Yana Y Kollet Neta N Gross Atan A Friedler Assaf A
The Journal of biological chemistry 20120313 18
The molecular basis of the interaction between mitochondrial carrier homologue 2 (MTCH2) and truncated BID (tBID) was characterized. These proteins participate in the apoptotic pathway, and the interaction between them may serve as a target for anticancer lead compounds. In response to apoptotic signals, MTCH2 recruits tBID to the mitochondria, where it activates apoptosis. A combination of peptide arrays screening with biochemical and biophysical techniques was used to characterize the mechanis ...[more]