Ontology highlight
ABSTRACT:
SUBMITTER: Kim ST
PROVIDER: S-EPMC3342345 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Kim Sun Taek ST Shin Yongdae Y Brazin Kristine K Mallis Robert J RJ Sun Zhen-Yu J ZY Wagner Gerhard G Lang Matthew J MJ Reinherz Ellis L EL
Frontiers in immunology 20120418
Mechanotransduction is a basis for receptor signaling in many biological systems. Recent data based upon optical tweezer experiments suggest that the TCR is an anisotropic mechanosensor, converting mechanical energy into biochemical signals upon specific peptide-MHC complex (pMHC) ligation. Tangential force applied along the pseudo-twofold symmetry axis of the TCR complex post-ligation results in the αβ heterodimer exerting torque on the CD3 heterodimers as a consequence of molecular movement at ...[more]