Dataset Information

The Effect of Friction on Actuation Torques of Foldable Rollover Protective Structures.

ABSTRACT: The number of fatal tractor rollover accidents with an inoperative foldable rollover protective structure (FROPS) has increased sharply in recent years. Operators frequently leave the FROPS in the folded-down position after lowering the FROPS to pass a low overhead obstacle. One possible explanation for leaving the FROPS in the folded position is that raising and lowering the FROPS is a time-consuming and strenuous process. The actuation torques required to raise and lower a FROPS are not well known and may be influenced by friction. The actuation torques of ten FROPS from four different models were measured. One model FROPS was tested on seven different vehicles, and three models were tested separately. The dynamic and static (initiation and holding) actuation torques were measured to evaluate the effect of static and kinetic friction on actuation torque. The dynamic actuation torques were measured before and after greasing the FROPS. The proposed instruction to measure the actuation torque based on OECD Code 7 was evaluated. Results showed that friction has a significant effect on the measured actuation torque and can increase the actuation torque by up to 212%. The friction varies between FROPS of the same model, which is due to variations in the manufacturing, maintenance, and age of the FROPS. The friction force could be decreased by greasing the FROPS, and decreasing the friction increased the lowering resisting torques and decreased raising torques of FROPS. The measured actuation torque based on OECD Code 7 instruction (static holding) is not a constant value. The dynamic method is recommended for measuring FROPS actuation torques.

SUBMITTER: Khorsandi F

PROVIDER: S-EPMC7384238 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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The Effect of Friction on Actuation Torques of Foldable Rollover Protective Structures.

Khorsandi Farzaneh F Ayers Paul D PD

Journal of agricultural safety and health 20180101 4

The number of fatal tractor rollover accidents with an inoperative foldable rollover protective structure (FROPS) has increased sharply in recent years. Operators frequently leave the FROPS in the folded-down position after lowering the FROPS to pass a low overhead obstacle. One possible explanation for leaving the FROPS in the folded position is that raising and lowering the FROPS is a time-consuming and strenuous process. The actuation torques required to raise and lower a FROPS are not well k ...[more]

PMID: 32719578

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Project description:In this work, a pair of gold(III) complexes derived from the analogous tetrapyridyl ligands H2biqbpy1 and H2biqbpy2 was prepared: the rollover, bis-cyclometalated [Au(biqbpy1)Cl ([1]Cl) and its isomer [Au(biqbpy2)Cl ([2]Cl). In [1]+, two pyridyl rings coordinate to the metal via a Au-C bond (C∧N∧N∧C coordination) and the two noncoordinated amine bridges of the ligand remain protonated, while in [2]+ all four pyridyl rings of the ligand coordinate to the metal via a Au-N bond (N∧N∧N∧N coordination), but both amine bridges are deprotonated. As a result, both complexes are monocationic, which allowed comparison of the sole effect of cyclometalation on the chemistry, protein interaction, and anticancer properties of the gold(III) compounds. Due to their identical monocationic charge and similar molecular shape, both complexes [1]Cl and [2]Cl displaced reference radioligand [3H]dofetilide equally well from cell membranes expressing the Kv11.1 (hERG) potassium channel, and more so than the tetrapyridyl ligands H2biqbpy1 and H2biqbpy2. By contrast, cyclometalation rendered [1]Cl coordinatively stable in the presence of biological thiols, while [2]Cl was reduced by a millimolar concentration of glutathione into metastable Au(I) species releasing the free ligand H2biqbpy2 and TrxR-inhibiting Au+ ions. The redox stability of [1]Cl dramatically decreased its thioredoxin reductase (TrxR) inhibition properties, compared to [2]Cl. On the other hand, unlike [2]Cl, [1]Cl aggregated into nanoparticles in FCS-containing medium, which resulted in much more efficient gold cellular uptake. [1]Cl had much more selective anticancer properties than [2]Cl and cisplatin, as it was almost 10 times more cytotoxic to human cancer cells (A549, A431, A375, and MCF7) than to noncancerous cells (MRC5). Mechanistic studies highlight the strikingly different mode of action of the two compounds: while for [1]Cl high gold cellular uptake, nuclear DNA damage, and interaction with hERG may contribute to cell killing, for [2]Cl extracellular reduction released TrxR-inhibiting Au+ ions that were taken up in minute amounts in the cytosol, and a toxic tetrapyridyl ligand also capable of binding to hERG. These results demonstrate that bis-cyclometalation is an appealing method to improve the redox stability of Au(III) compounds and to develop gold-based cytotoxic compounds that do not rely on TrxR inhibition to kill cancer cells.

Dataset Information

The Effect of Friction on Actuation Torques of Foldable Rollover Protective Structures.

Publications

The Effect of Friction on Actuation Torques of Foldable Rollover Protective Structures.

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