Ontology highlight
ABSTRACT:
SUBMITTER: Mallette FA
PROVIDER: S-EPMC3343333 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Mallette Frédérick A FA Mattiroli Francesca F Cui Gaofeng G Young Leah C LC Hendzel Michael J MJ Mer Georges G Sixma Titia K TK Richard Stéphane S
The EMBO journal 20120228 8
In response to DNA damage, cells initiate complex signalling cascades leading to growth arrest and DNA repair. The recruitment of 53BP1 to damaged sites requires the activation of the ubiquitination cascade controlled by the E3 ubiquitin ligases RNF8 and RNF168, and methylation of histone H4 on lysine 20. However, molecular events that regulate the accessibility of methylated histones, to allow the recruitment of 53BP1 to DNA breaks, are unclear. Here, we show that like 53BP1, the JMJD2A (also k ...[more]