Ontology highlight
ABSTRACT:
SUBMITTER: Nowsheen S
PROVIDER: S-EPMC6083879 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Nowsheen Somaira S Aziz Khaled K Aziz Asef A Deng Min M Qin Bo B Luo Kuntian K Jeganathan Karthik B KB Zhang Henan H Liu Tongzheng T Yu Jia J Deng Yibin Y Yuan Jian J Ding Wei W van Deursen Jan M JM Lou Zhenkun Z
Nature cell biology 20180326 4
Cells respond to cytotoxic DNA double-strand breaks (DSBs) by recruiting DNA repair proteins to the damaged site. This recruitment is dependent on ubiquitylation of adjacent chromatin areas by E3 ubiquitin ligases such as RNF8 and RNF168, which are recruited sequentially to the DSBs. However, it is unclear what dictates the sequential order and recruits RNF168 to the DNA lesion. Here, we reveal that L3MBTL2 (lethal(3)malignant brain tumour-like protein 2) is the missing link between RNF8 and RNF ...[more]