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2-Amino-4-(4-chloro-phen-yl)-6-(pyrrolidin-1-yl)pyridine-3,5-dicarbonitrile.

ABSTRACT: In the title compound, C(17)H(14)ClN(5), two C atoms and their attached H atoms of the pyrrolidine ring are disordered over two sets of sites with an occupancy ratio of 0.638 (10):0.362 (10). The benzene and pyridine rings are inclined to one another by 60.57 (8)°. In the crystal, the amino group forms an N-H⋯N hydrogen bond with one of the cyano groups, linking the mol-ecules into chains along [010].

SUBMITTER: Inglebert SA

PROVIDER: S-EPMC3343967 | biostudies-literature |

REPOSITORIES: biostudies-literature

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2-Amino-6-(pyrrolidin-1-yl)-4-p-tolyl-pyridine-3,5-dicarbonitrile.

Project description:In the title compound, C(18)H(17)N(5), the pyrrolidine ring adopts an envelope conformation. The pyrrolidine ring is disordered over two sets of sites with occupancy factors of 0.648?(6) and 0.352?(6). The dihedral angles between the pyrrolidine and pyridine rings are 14.6?(3)° for the major component and 16.2?(6)° for the ninor component. The crystal structure is stabilized by inter-molecular N-H?N and C-H?N inter-actions.

| S-EPMC3213431 | biostudies-literature

6-Amino-4-(4-chloro-phen-yl)-2-oxo-1,2-dihydro-pyridine-3,5-dicarbonitrile ethanol solvate.

Project description:The title compound, C(13)H(7)ClN(4)O·C(2)H(6)O, was synthesized by the reaction of 4-chloro-benzaldehyde, malononitrile and 10% sodium hydroxide solution in an aqueous medium. In the crystal structure, the crystal packing is stabilized by inter-molecular N-H?N, O-H?O and N-H?O hydrogen bonds.

| S-EPMC2962196 | biostudies-other

2-Amino-6-(dimethyl-amino)pyridine-3,5-dicarbonitrile.

Project description:The title compound, C(9)H(9)N(5), is slightly twisted from planarity, with a maximum deviation of 0.0285?(13)?Å from the pyridine plane for the C atom bearing the amino group. The cyano groups are on different sides of the pyridine plane, with C- and N-atom deviations of 0.072?(3)/0.124?(4) and -0.228?(4)/-0.409?(5)?Å from the pyridine plane. In the crystal, N-H?N and C-H?N hydrogen bonds connect the mol-ecules into zigzag chains running along the c axis.

| S-EPMC3344634 | biostudies-literature

2,6-Di-amino-4-(4-chloro-phen-yl)-1-methyl-1,4-di-hydro-pyridine-3,5-dicarbo-nitrile.

Project description:In the title compound, C14H12ClN5, the di-hydro-pyridine ring adopts a shallow boat conformation. The dihedral angle between the plane of this ring and that of the chloro-benzene ring is 69.15?(15)°. In the crystal, mol-ecules are linked by N-H?N and N-H?Cl hydrogen bonds, generating (001) sheets.

| S-EPMC4120602 | biostudies-literature

2-(Piperidin-1-yl)-6-(1H-pyrrol-1-yl)pyridine-3,5-dicarbonitrile.

Project description:The piperidine ring of the title compound, C(16)H(15)N(5), adopts a chair conformation. The pyridine ring is essentially planar, with a maximum deviation of 0.035 (3) Å. The pyrrole and pyridine rings are almost coplanar, forming a dihedral angle of 3.48 (14)°. In the crystal, no classical hydrogen bonds were found. In the crystal, the molecules are linked by aromatic π-π stacking [centroid-centroid separations = 3.4984 (16) and 3.9641 (15) Å between pyrrole and pyridine rings and between pyridine rings, respectively].

| S-EPMC3343920 | biostudies-literature

2-(Morpholin-4-yl)-6-(1H-pyrrol-1-yl)-pyridine-3,5-dicarbonitrile.

Project description:In the title compound, C(15)H(13)N(5)O, the morpholine ring adopts a chair conformation. The dihedral angle between the pyrrole ring and the pyridine ring is 28.93 (14)°. In the crystal, the molecules are linked by C-H⋯O hydrogen bonds occur, and aromatic weak π-π stacking [centroid-centroid separation = 4.178 (2) Å] and C-H⋯π inter-actions consolidate the packing.

| S-EPMC3297933 | biostudies-literature

2,6-Diphenyl-4-(2-thien-yl)-1,4-dihydro-pyridine-3,5-dicarbonitrile.

Project description:The asymmetric unit of the title compound, C(23)H(15)N(3)S, contains two crystallographically independent mol-ecules. The pyridine rings adopt envelope conformations. The thio-phene rings are oriented at dihedral angles of 77.97?(4)/53.53?(4) and 78.44?(4)/57.11?(4)° with respect to the phenyl rings, while the dihedral angles between the phenyl rings are 48.51?(4) and 44.49?(4)°. In the crystal structure, inter-molecular N-H?N hydrogen bonds link the mol-ecules into chains along the c axis. The S, C and H atoms of one of the thio-phene rings are disordered over two orientations, with occupancy ratios of 0.314?(15):0.686?(15).

| S-EPMC2970109 | biostudies-literature

2-Amino-4-(4-chloro-phen-yl)-5,6,7,8,9,10-hexa-hydro-benzo[8]annulene-1,3-dicarbonitrile.

Project description:In the title compound, C(20)H(18)ClN(3), the cyclo-octene ring exhibits conformational disorder of two methyl-ene groups with a site-occupation factor of 0.859 (6) for the major occupied site. In the crystal, mol-ecules are connected into inversion dimers via pairs of weak N-H⋯N hydrogen bonds, forming an R(2) (2)(12) graph-set motif. These dimers are further connected via weak N-H⋯Cl inter-actions into chains running along [011]. There are also C-H⋯N interactions present in the crystal.

| S-EPMC3435713 | biostudies-literature

2-Amino-4-(4-chloro-phen-yl)-5,6-dihydro-benzo[h]quinoline-3-carbonitrile-3-amino-1-(4-chloro-phen-yl)-9,10-dihydro-phenanthrene-2,4-dicarbonitrile (1/4).

Project description:The asymmetric unit of the 1:4 title co-crystal of 2-amino-4-(4-chloro-phen-yl)-5,6-dihydro-benzo[h]quinoline-3-carbonitrile and 3-amino-1-(4-chloro-phen-yl)-9,10-dihydro-phenanthrene-2,4-dicarbonitrile, 0.2C(20)H(14)ClN(3)·0.8C(22)H(14)ClN(3), has the atoms of the fused-ring system and those of the amino, cyano and chloro-phenyl substitutents overlapped. The fused-ring system is buckled owing to the ethyl-ene linkage in the central ring. There are two independent overlapped mol-ecules in the asymmetric unit. In one independent mol-ecule, the two flanking aromatic rings are twisted by 24.4?(1)° and the ring of the chloro-phenyl substituent is twisted by 87.3?(1)° relative to the amino- and cyano-bearing aromatic ring. In the second mol-ecule, the respective dihedral angles are 26.1?(1) and 57.8?(1)°. The two independent mol-ecules are linked by N-H?N hydrogen bonds into dimers.

| S-EPMC3247609 | biostudies-literature

2-Amino-4-(2-chloro-phen-yl)-6-(naph-thalen-1-yl)pyridine-3-carbonitrile.

Project description:In the title compound, C(22)H(14)ClN(3), prepared by a one-pot reaction under microwave irradiation, the dihedral angles between the central pyridine ring and the pendant naphthyl and chloro-benzene ring systems are 49.2?(2) and 58.2?(3)°, respectively. In the crystal, inversion dimers linked by pairs of N-H?N hydrogen bonds generate R(2) (2)(8) loops. The pyridine N atom is the acceptor.

| S-EPMC3379409 | biostudies-literature

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