Ontology highlight
ABSTRACT:
SUBMITTER: Pinc A
PROVIDER: S-EPMC3345981 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Pinc Alice A Somasundaram Rajasekharan R Wagner Christine C Hörmann Marcus M Karanikas Georgios G Jalili Ahmad A Bauer Wolfgang W Brunner Patrick P Grabmeier-Pfistershammer Katharina K Gschaider Melanie M Lai Chiou-Yan CY Hsu Mei-Yu MY Herlyn Meenhard M Stingl Georg G Wagner Stephan N SN
Molecular therapy : the journal of the American Society of Gene Therapy 20120221 5
Melanomas contain distinct cell subpopulations. Several of these subpopulations, including one expressing CD20, may harbor stem cell-like or tumor-initiating characteristics. We hypothesized that patients at high risk of disease recurrence could benefit from an adjuvant anti-CD20 therapy. Therefore, we initiated a small pilot trial to study the effect of the anti-CD20 antibody rituximab in a group of melanoma patients with stage IV metastatic disease who had been rendered without evident disease ...[more]