Ontology highlight
ABSTRACT:
SUBMITTER: Koberle M
PROVIDER: S-EPMC3346162 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Köberle Martin M Kaesler Susanne S Kempf Wolfgang W Wölbing Florian F Biedermann Tilo T
Frontiers in immunology 20120507
Mast cells (MC) are key mediators of the immune system, most prominently known for their role in eliciting harmful allergic reactions. Mast cell mediator release (e.g. by degranulation) is triggered by FcεRI recognition of antigen - IgE complexes. Until today no therapeutic targeting of this and other mast cell activation pathways is established. Among possible new candidates there are tetraspanins that have been described on MC already several years ago. Tetraspanins are transmembrane proteins ...[more]