Ontology highlight
ABSTRACT:
SUBMITTER: Bellows-Peterson ML
PROVIDER: S-EPMC3349770 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Bellows-Peterson Meghan L ML Fung Ho Ki HK Floudas Christodoulos A CA Kieslich Chris A CA Zhang Li L Morikis Dimitrios D Wareham Kathryn J KJ Monk Peter N PN Hawksworth Owen A OA Woodruff Trent M TM
Journal of medicinal chemistry 20120420 9
Targeting the complement component 3a receptor (C3aR) with selective agonists or antagonists is believed to be a viable therapeutic option for several diseases such as stroke, heart attack, reperfusion injuries, and rheumatoid arthritis. We designed a number of agonists, partial agonists, and antagonists of C3aR using our two-stage de novo protein design framework. Of the peptides tested using a degranulation assay in C3aR-transfected rat basophilic leukemia cells, two were prominent agonists (E ...[more]