Ontology highlight
ABSTRACT:
SUBMITTER: Lloyd TE
PROVIDER: S-EPMC3353876 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Lloyd Thomas E TE Machamer James J O'Hara Kathleen K Kim Ji Han JH Collins Sarah E SE Wong Man Y MY Sahin Brooke B Imlach Wendy W Yang Yunpeng Y Levitan Edwin S ES McCabe Brian D BD Kolodkin Alex L AL
Neuron 20120401 2
p150(Glued) is the major subunit of dynactin, a complex that functions with dynein in minus-end-directed microtubule transport. Mutations within the p150(Glued) CAP-Gly microtubule-binding domain cause neurodegenerative diseases through an unclear mechanism. A p150(Glued) motor neuron degenerative disease-associated mutation introduced into the Drosophila Glued locus generates a partial loss-of-function allele (Gl(G38S)) with impaired neurotransmitter release and adult-onset locomotor dysfunctio ...[more]