Ontology highlight
ABSTRACT:
SUBMITTER: Ma CS
PROVIDER: S-EPMC3355712 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Ma Cindy S CS Avery Danielle T DT Chan Anna A Batten Marcel M Bustamante Jacinta J Boisson-Dupuis Stephanie S Arkwright Peter D PD Kreins Alexandra Y AY Averbuch Diana D Engelhard Dan D Magdorf Klaus K Kilic Sara S SS Minegishi Yoshiyuki Y Nonoyama Shigeaki S French Martyn A MA Choo Sharon S Smart Joanne M JM Peake Jane J Wong Melanie M Gray Paul P Cook Matthew C MC Fulcher David A DA Casanova Jean-Laurent JL Deenick Elissa K EK Tangye Stuart G SG
Blood 20120308 17
T follicular helper (Tfh) cells are critical for providing the necessary signals to induce differentiation of B cells into memory and Ab-secreting cells. Accordingly, it is important to identify the molecular requirements for Tfh cell development and function. We previously found that IL-12 mediates the differentiation of human CD4(+) T cells to the Tfh lineage, because IL-12 induces naive human CD4(+) T cells to acquire expression of IL-21, BCL6, ICOS, and CXCR5, which typify Tfh cells. We have ...[more]