Ontology highlight
ABSTRACT:
SUBMITTER: Ray JP
PROVIDER: S-EPMC3992517 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Ray John P JP Marshall Heather D HD Laidlaw Brian J BJ Staron Matthew M MM Kaech Susan M SM Craft Joe J
Immunity 20140313 3
Follicular helper T (Tfh) cells are required for the establishment of T-dependent B cell memory and high affinity antibody-secreting cells. We have revealed herein opposing roles for signal transducer and activator of transcription 3 (STAT3) and type I interferon (IFN) signaling in the differentiation of Tfh cells following viral infection. STAT3-deficient CD4(+) T cells had a profound defect in Tfh cell differentiation, accompanied by decreased germinal center (GC) B cells and antigen-specific ...[more]