Ontology highlight
ABSTRACT:
SUBMITTER: Grindrod S
PROVIDER: S-EPMC3356144 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Grindrod Scott S Suy Simeng S Fallen Shannon S Eto Masumi M Toretsky Jeffrey J Brown Milton L ML
Frontiers in oncology 20110920
Myosin light chain phosphatase (MLCP) is an enzyme important to regulation of cell cycle and motility that is shown to be upregulated in aggressive prostate cancer cells and tissue. We developed a fluorescent small molecule inhibitor of MLCP using structure based design in recombinant protein phosphatase 1C. Several best fit compounds were synthesized and evaluated by their inhibition of MLCP/(32)P-MLC dephosphorylation, which resulted in the identification of novel MLCP inhibitors. Androgen dep ...[more]